Bioprocessing

An overview of Upstream and Downstream Processing

Colton Baumler

ccbaumler@ucdavis.edu

University of California, Davis

Monday, the 13^th of April, 2026

Learning Objectives

1. Modeling the overall process
2. Define Bioprocessing
3. Understand the variety of biological systems and products
4. Critically evaluate process requirements

Modeling the Overall Process

In a single word, write a theme for each quote?

Modeling the Overall Process

Everything is everywhere, but the environment selects.

• Baas Becking
  • Plant physiologist
    • Geobiology
• Growth

Perfection is achieved, not when there is nothing more to add, but when there is nothing left to take away.

• Antoine de Saint-Exupéry
  • Writer and Aviator
    • Wind, Sand, and Stars
• Refinement

Growth and Refinement define Bioprocessing

Modeling the Overall Process

Painted by David Goodsell. The composition of macromolecules is depicted to scale, with an effort to show the impact of native concentrations of macromolecules on the environment; Histone Like Proteins in Gold, white strands are mRNA, purple are ribosomes, and enzymes are in blue.

Before bioprocesses, what are processes?

Modeling the Overall Process

Bioprocess

Bioprocess

Defining Bioprocessing

Applications in pharma, science, biofuel, vaccine, and food products

This is how we make vitamins, insulin, biofuel, growth hormones, anitbiotics

What is Bioprocessing?

Defining Bioprocessing

A technique to use biological resources to create and isolate products.

What is Bioprocessing?

Defining Bioprocessing

A technique to use biological resources to create and isolate products.

Key Components:

• Biological Resources
  • Bacterial, mammalian, or plant cells
  • Viruses
  • Cell-free systems
• Products
  • Antibodies, proteins, and metabolites
  • Applications in pharma, science, biofuel, vaccine, and food products

Understand the variety of biological systems and products

Critically evaluate process requirements

Appendix

Glossary